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Request PDF on ResearchGate | Intérêt des acides biliaires dans la cholestase gravidique | Intrahepatic cholestasis during pregnancy is a risk factor for. La cholestase gravidique a été reliée à des critères de jugement maternels et fœtaux/néonatals indésirables. Du fait que la physiopathologie est mal comprise, . Interventions pour le traitement de la cholestase gravidique. This is not the most recent version of this Review. view the current version 24 June

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It is slightly more frequent during twin pregnancies.

Access to the text HTML. Liver tests are abnormal, with mainly an increase in serum transaminases and bile acids.


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Treatment by the bile acid ursodeoxycholic acid improves pruritus and decreases the frequency of fetal complications, without side effects in the mother or baby. Personal information regarding our website’s visitors, including their identity, is confidential. The susceptibility is explained by polymorphisms of genes encoding hepatocytic transport proteins that are important for bile secretion. Besides disturbing pruritus, maternal prognosis is good. As per the Law relating to information storage and personal integrity, you have the right to oppose art 26 of that lawaccess art 34 of that law and rectify art 36 of that law your personal data.


Clinical signs and biochemical abnormalities normalize rapidly after delivery, at most after 3 to 4 weeks.

Hépato-Gastro & Oncologie Digestive

In forms with severe pruritus, early delivery by induced labor between 37 and 38 weeks may be necessary. Its prevalence in France is of the order of 1 per pregnancies. Journal page Archives Contents list. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.

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La cholestase gravidique – EM|consulte

Contact Help Who are we? La cholestase gravidique Intrahepatic cholestasis of pregnancy. If you want to subscribe to this journal, see our rates You can purchase this item in Pay Per View: Cholestasis of pregnancy presents with pruritus, sometimes incapacitating, less frequently by jaundice.

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Gravity of the disease comes from the occurrence of fetal complications, in particular prematurity often gravidiqje by obstetrical teams and gravidiquw pulmonary complications, and sudden intra-uterine fetal death.

Elle survient pendant le 2 e ou le 3 e trimestre de la grossesse. The disease is probably due to susceptibility to estrogens and progesterone, whose serum concentration is elevated during pregnancy and which are cholestatic. Bile acids, Ursodeoxycholic acid, Prematurity, Pruritus.

It occurs during the second or third trimester.